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Human PDGF-AB
100-00AB
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Артикул: 100-00AB

Производитель: PeproTech

Фасовка: BUL100

CAS: 100-00AB-100µG

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet ?-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-? and PDGFR-?. PDGFR-? is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-? interacts with only PDGF-BB and PDGF-AB.

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Human PDGF-AB
100-00AB
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Артикул: 100-00AB

Производитель: PeproTech

Фасовка: STDB

CAS: 100-00AB-10µG

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet ?-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-? and PDGFR-?. PDGFR-? is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-? interacts with only PDGF-BB and PDGF-AB.

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Human PDGF-AB
100-00AB
Под заказ

Артикул: 100-00AB

Производитель: PeproTech

Фасовка: BUL1MG

CAS: 100-00AB-1MG

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet ?-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-? and PDGFR-?. PDGFR-? is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-? interacts with only PDGF-BB and PDGF-AB.

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Human PDGF-AB
100-00AB
Под заказ

Артикул: 100-00AB

Производитель: PeproTech

Фасовка: STDA

CAS: 100-00AB-2µG

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet ?-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-? and PDGFR-?. PDGFR-? is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-? interacts with only PDGF-BB and PDGF-AB.

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Human PDGF-AB
100-00AB
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Артикул: 100-00AB

Производитель: PeproTech

Фасовка: BUL50

CAS: 100-00AB-50µG

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet ?-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-? and PDGFR-?. PDGFR-? is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-? interacts with only PDGF-BB and PDGF-AB.

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Human PDGF-CC
100-00CC
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Артикул: 100-00CC

Производитель: PeproTech

Фасовка: BUL100

CAS: 100-00CC-100µG

The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel, disulfide-linked dimer of two 12-14 kDa, polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-? and PDGFR-?, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules' epithelial cell development. Mature PDGFs are stored in platelet ?-granules, and are released upon platelet activation. PDGF-AA, -AB, -BB and -CC signal primarily through the PDGF-R? receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-R? receptor.

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Human PDGF-CC
100-00CC
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Артикул: 100-00CC

Производитель: PeproTech

Фасовка: BUL1MG

CAS: 100-00CC-1MG

The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel, disulfide-linked dimer of two 12-14 kDa, polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-? and PDGFR-?, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules' epithelial cell development. Mature PDGFs are stored in platelet ?-granules, and are released upon platelet activation. PDGF-AA, -AB, -BB and -CC signal primarily through the PDGF-R? receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-R? receptor.

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Human PDGF-CC
100-00CC
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Артикул: 100-00CC

Производитель: PeproTech

Фасовка: STDB

CAS: 100-00CC-20µG

The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel, disulfide-linked dimer of two 12-14 kDa, polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-? and PDGFR-?, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules' epithelial cell development. Mature PDGFs are stored in platelet ?-granules, and are released upon platelet activation. PDGF-AA, -AB, -BB and -CC signal primarily through the PDGF-R? receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-R? receptor.

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Human PDGF-CC
100-00CC
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Артикул: 100-00CC

Производитель: PeproTech

Фасовка: STDA

CAS: 100-00CC-5µG

The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel, disulfide-linked dimer of two 12-14 kDa, polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-? and PDGFR-?, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules' epithelial cell development. Mature PDGFs are stored in platelet ?-granules, and are released upon platelet activation. PDGF-AA, -AB, -BB and -CC signal primarily through the PDGF-R? receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-R? receptor.

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Human sCD22
100-01
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Артикул: 100-01

Производитель: PeproTech

Фасовка: BUL100

CAS: 100-01-100µG

CD22 is a B-lineage restricted 135 kDa glycoprotein whose cell surface expression is limited to resting and activated B lymphocytes. The physiological role of CD22 is still unknown. Targeted disruption of CD22 in mice results in a reduced level of surface IgM on peripheral B cells, suggesting a role for CD22 in limiting antigen receptor signaling. CD22 is a member of the Ig gene superfamily that uniquely binds a sialic acid-dependent ligand.

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Human sCD22
100-01
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Артикул: 100-01

Производитель: PeproTech

Фасовка: BUL1MG

CAS: 100-01-1MG

CD22 is a B-lineage restricted 135 kDa glycoprotein whose cell surface expression is limited to resting and activated B lymphocytes. The physiological role of CD22 is still unknown. Targeted disruption of CD22 in mice results in a reduced level of surface IgM on peripheral B cells, suggesting a role for CD22 in limiting antigen receptor signaling. CD22 is a member of the Ig gene superfamily that uniquely binds a sialic acid-dependent ligand.

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Human sCD22
100-01
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Артикул: 100-01

Производитель: PeproTech

Фасовка: STDB

CAS: 100-01-20µG

CD22 is a B-lineage restricted 135 kDa glycoprotein whose cell surface expression is limited to resting and activated B lymphocytes. The physiological role of CD22 is still unknown. Targeted disruption of CD22 in mice results in a reduced level of surface IgM on peripheral B cells, suggesting a role for CD22 in limiting antigen receptor signaling. CD22 is a member of the Ig gene superfamily that uniquely binds a sialic acid-dependent ligand.

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Human sCD22
100-01
Под заказ

Артикул: 100-01

Производитель: PeproTech

Фасовка: STDA

CAS: 100-01-5µG

CD22 is a B-lineage restricted 135 kDa glycoprotein whose cell surface expression is limited to resting and activated B lymphocytes. The physiological role of CD22 is still unknown. Targeted disruption of CD22 in mice results in a reduced level of surface IgM on peripheral B cells, suggesting a role for CD22 in limiting antigen receptor signaling. CD22 is a member of the Ig gene superfamily that uniquely binds a sialic acid-dependent ligand.

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Human Heregulin-beta 1
100-03
Под заказ

Артикул: 100-03

Производитель: PeproTech

Фасовка: BUL100

CAS: 100-03-100µG

Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-?1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-?1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF).

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Human Heregulin-beta 1
100-03
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Артикул: 100-03

Производитель: PeproTech

Фасовка: STDA

CAS: 100-03-10µG

Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-?1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-?1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF).

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