4,4'-DIISOTHIOCYANATOSTILBENE-2,2'- &

Description_x000D_ Application_x000D_ 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate has been used:_x000D_ • as band3 protein inhibitor in rabbits(19)_x000D_ • for the inhibition of bicarbonate transporters in brain slice tissue(20)_x000D_ • as HCO3-/Cl- exchanger (anion exchanger) in embryos(21)_x000D_ A negatively charged homobifunctional cross-linking reagent. The isothiocyanate groups react with primary amines at pH 9.0-10.0._x000D_ Packaging_x000D_ 1 g in poly bottle_x000D_ 100, 250 mg in poly bottle_x000D_ 25 mg in glass insert_x000D_ Biochem/physiol Actions_x000D_ 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid is an anionic alkylating agent containing isothiocyanate residue. It is a negatively charged homobifunctional cross-linking reagent. 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid is a specific inhibitor of cellular anion permeability used in cell transport studies. The isothiocyanate groups react with primary amines at pH 9.0-10.0. 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid alkylates lysine residues and inhibits apoptosis indirectly by targeting membrane based anion transporters.In addition, it also inhibits calcium transport in vesicles._x000D_ A specific inhibitor of cellular anion permeability used in cell transport studies.