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Description_x000D_
General description_x000D_
CD166 antigen (UniProt: Q13740; also known as Activated leukocyte cell adhesion molecule, CD166) is encoded by the ALCAM (also known as MEMD) gene (Gene ID: 214) in human. CD166 is a cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6 and homotypic cell-cell contacts. It also promotes T-cell activation and proliferation via its interactions with CD6 and is shown to be involved in the formation and maturation of the immunological synapse via its interactions with CD6. CD166 mediates attachment of dendritic cells onto endothelial cells via homotypic interaction and inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. It has an extracellular (aa 28-527), transmembrane (aa 528-549), and a cytoplasmic (aa 550-583) domain. CD166 is expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. It is also detected on hematopoietic stem cells derived from umbilical cord blood, on lymph vessel endothelial cells, skin and tonsil, and on peripheral blood monocytes. Lower levels of CD166 are detected in spleen, placenta, and liver. CD166 is also detected in highly metastasizing melanoma cell lines._x000D_
Specificity_x000D_
Clone TAG-1A3 specifically detects CD166 in human._x000D_
Immunogen_x000D_
Corneal endothelial cells (hCENC) isolated from donated human cadaves and immunized with monophosphoryl-lipid A trehalose dicorynomycolate (MPLCTDM) adjuvant._x000D_
Application_x000D_
Anti-CD166 (ALCAM) Antibody, clone TAG-1A3, Cat. No. MABN1785, is a highly specific mouse monoclonal antibody that targets CD166 and has been tested in Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, and Western Blotting._x000D_
Flow Cytometry Analysis: A representative lot detected CD166 (ALCAM) in Flow Cytometry applications (Ding, Y., et. al. (2014). MAbs. 6(6):1439-52)._x000D_
Immunocytochemistry Analysis: A representative lot detected CD166 (ALCAM) in Immunocytochmistry applications (Ding, Y., et. al. (2014). MAbs. 6(6):1439-52)._x000D_
Immunoprecipitation Analysis: A representative lot detected CD166 (ALCAM) in Immunoprecipitation applications (Ding, Y., et. al. (2014). MAbs. 6(6):1439-52)._x000D_
Flow Cytometry Analysis: A represetative lot detected CD166 (ALCAM) in human embryonic stem cells, human corneal stromal fibroblast (hCSF) cells, immortalized human corneal endothelial cells (B4G12), and human endothelial cells from donors (2) (Courtesy of Dr. Vanessa Ding, Ph.D. and Dr. Andre Choo, Ph.D, BTI, Singapore)._x000D_
Immunofluorescence Analysis: A representative lot detected CD166 (ALCAM) in Immunofluorescence applications (Ding, Y., et. al. (2014). MAbs. 6(6):1439-52)._x000D_
Western Blotting Analysis: A representative lot detected CD166 (ALCAM) in Western Blotting applications (Ding, Y., et. al. (2014). MAbs. 6(6):1439-52)._x000D_
Research Category_x000D_
Neuroscience_x000D_
Target description_x000D_
~80 kDa observed; 65.10 kDa calculated. Uncharacterized bands may be observed in some lysate(s)._x000D_
Physical form_x000D_
Format: Purified_x000D_
Protein G purified_x000D_
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide._x000D_
Storage and Stability_x000D_
Stable for 1 year at 2-8°C from date of receipt._x000D_
Disclaimer_x000D_
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_
Quality_x000D_
Identity Confirmation by Isotyping Test._x000D_
Isotyping Analysis: The identity of this monoclonal antibody is confirmed by isotyping test to be human IgG1 ._x000D_
Other Notes_x000D_
Concentration: Please refer to lot specific datasheet.
- Related Categories Alphabetical Index, Antibodies, CD0-CDC, Primary Antibodies clone