ANTI-CIKS (AB2)

Description_x000D_ General description_x000D_ CIKS (connection to IKK (IκB kinase) and SAPK (stress-activated protein kinase) /JNK (jun kinase)) is a cytoplasmic protein, that exists in the nucleus. It is also termed as Act1(NF-κB activator 1) and TRAF3IP2 (TRAF3 interacting protein 2). It is located on chromosome 6q21._x000D_ Immunogen_x000D_ a synthetic peptide corresponding to amino acids 2-15 of human CIKS._x000D_ Physical form_x000D_ Solution in phosphate buffered saline containing 0.02% sodium azide_x000D_ Biochem/physiol Actions_x000D_ CIKS (connection to IKK (IκB kinase) and SAPK (stress-activated protein kinase) /JNK (jun kinase)) is susceptible to various diseases like psoriasis and psoriatic arthritis. It is responsible for the cardiomyocyte growth, fibroblast migration and proliferation, promoted by aldosterone. It participates in the signaling function of IL-17 (interleukin) cytokine family. It can act as a transcriptional enhancer due to its presence in the nuclear compartment of airway epithelial cells._x000D_ Linkage_x000D_ The action of this antibody can be blocked using blocking peptide SBP2501.