Description_x000D_ General description_x000D_ Duffy antigen/chemokine receptor (DARC) or atypical chemokine receptor 1 (ACKR1) is a membrane-bound protein. The gene encoding this chemokine receptor is localized on human chromosome 1q23.2._x000D_ Immunogen_x000D_ Peptide with sequence HRAELSPSTENSSQLDFED-C from the N Terminus of the protein sequence according to NP_002027.2._x000D_ Physical form_x000D_ Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Duffy antigen/chemokine receptor (DARC) or atypical chemokine receptor 1 (ACKR1) functions as an antigen of the Duffy (Fy) blood group system. It has a role in the infection of red blood cells (RBCs) by Plasmodium vivax and the lysis of RBCs by Staphylococcus aureus. The protein has been shown to be downregulated in colorectal cancer._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.