Description_x000D_ General description_x000D_ Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues such as skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex. In human, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. FZD7 is expressed throughout normal gastrointestinal tract, from esophagus to rectum. It is highly expressed in the gastric cancer cell line MKN7 and relatively lowers in esophageal cancer cell lines._x000D_ Immunogen_x000D_ synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-7, conjugated to KLH. The immunizing peptide has 100% homology with the mouse gene._x000D_ Application_x000D_ Anti-Frizzled-7 antibody is suitable for immunostaining of liver tissues to localise FZD7 in T and pT tissues. It is also suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 4μg/mL using human kidney._x000D_ Physical form_x000D_ Solution in phosphate buffered saline containing 0.01% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ FZD7 shows 98.8% nucleotide identity with FzE3 and encodes for WNT receptors with nine amino-acid substitutions. In human primary gastric cancer, high level of FZD7 has been found. Mechanistically, over-expression of Frizzled-7 accelerates the WNT-β-catenin-TCF pathway. Through the activation of the WNT-β-catenin-TCF pathway, FZD7, might play key roles in carcinogenesis.