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Description_x000D_
General description_x000D_
GRP78/BiP is a Ca2+-binding molecular chaperone located in the endoplasmic reticulum (ER). It is a highly conserved protein._x000D_
Application_x000D_
Anti-GRP78/BiP (GL-19) antibody produced in rabbit has been used in:_x000D_
• western blotting_x000D_
• immunocytochemistry_x000D_
• immunohistochemistry_x000D_
Physical form_x000D_
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_
Disclaimer_x000D_
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_
Packaging_x000D_
200 μL in glass bottle_x000D_
Biochem/physiol Actions_x000D_
GRP78 (78-kDa glucose-regulated protein) is essential for cell viability. GRP78/BiP is induced by stress-inducing agents or by conditions that adversely affect endoplasmic reticulum(ER) function, including oxidative stress, chemical toxicity, Ca2+ ionophores, inhibition of the ER Ca2+ -ATPase, inhibitors of glycosylation and hypoxia. GRP78/BiP is critical for maintenance of Ca2+ homeostasis and the prevention of apoptosis. GRP78/BiP levels are reduced in Alzheimer′s disease brains and the decreased expression of GRP78/BiP is found associated with mis-sense mutations in presenilin-1 (PS-1).
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