Description_x000D_ General description_x000D_ Anti-JAK2 Antibody detects endogenous levels of total JAK2 protein._x000D_ JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the Jak family of proteins. The JAK2 gene is located on human chromosome 9p24._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human JAK2._x000D_ Immunogen Range: 981-1030_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Biochem/physiol Actions_x000D_ JAK2 (janus kinase 2) plays an important role in the activities of cytokine receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.