Description_x000D_ General description_x000D_ p27(Kip1) is a cyclin-dependent kinase inhibitor involved in G1 arrest. p27(Kip1) binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4. p27(Kip1) is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27(Kip1); while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm._x000D_ Specificity_x000D_ Recognizes Kip1._x000D_ Immunogen_x000D_ An 18 amino acid synthetic peptide ([C]GSVEQTPKKPGLRRRQT) linked to KLH was used to immunize rabbits_x000D_ Application_x000D_ Anti-Kip1 (p27) Antibody is a high quality Rabbit Polyclonal Antibody for the detection of Kip1 (p27) & has been validated in IHC, IP & WB._x000D_ Target description_x000D_ 27 kDa_x000D_ Physical form_x000D_ Format: Purified_x000D_ Quality_x000D_ routinely evaluated by immunoblot on HeLa nuclear extract or in rabbit brain nuclear extract_x000D_ Linkage_x000D_ Replaces: 04-240_x000D_ Other Notes_x000D_ Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.