Description_x000D_ General description_x000D_ Breast cancer antiestrogen resistance 1 (BCAR1), also known as p130 Cas, is encoded by the gene mapped to human chromosome 16q23. BCAR1 belongs to Cas (Crk-associated substrate) protein family. The protein is characterized with an amino-terminal Src homology 3 (SH3) domain, a Src-binding domain, a large substrate domain, and a helix-loop-helix domain._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human p130 Cas around the phosphorylation site of Tyr410._x000D_ Immunogen Range: 376-425_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Breast cancer antiestrogen resistance 1 (BCAR1), also known as p130 Cas, plays a vital role in various cellular processes such as migration, adhesion, cytoskeleton reorganization host-pathogen interaction, survival, proliferation, transformation, and possibly metastasis. It is associated with the growth factor receptor EGFR and the metastasis suppressor KAI1, in vitro. Overexpression of BCAR1 in localized prostate cancers (LPC) suggests that this protein has potential as a marker for both prognosis and treatment. It is also considered to be a potential marker for breast cancer. Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) and BCAR1, via SRC, promote removal of E-Cadherin from cell membrane, and trigger E-cadherin degradation._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.