Кат. №: HPA025072-100UL-100.0
Description General description The gene XKR4 (XK related 4) is mapped to human chromosome 8q12.1. It is mainly expressed in the brain, esophagus and stomach. Low levels of XKR4 are also present in the thyroid, kidney and pancreas. Immunogen XK-related protein 4 recombinant protein epitope signature tag (PrEST) Application All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige. Physical form Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide Legal Information Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC Biochem/physiol Actions Polymorphisms in XKR4 (XK related 4) gene are associated with low levels of TSH (thyroid-stimulating hormone) in the serum. Additionally, polymorphisms in this gene might also be linked with ADHD (attention deficit/hyperactivity disorder). Features and Benefits Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. • Validated for multiple commonly used applications such as IHC (Immunohistochemistry), IF (Immunofluorescence), and WB (Western Blot) Linkage Corresponding Antigen APREST76470.
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