BERBERINE CHLORIDE

Description General description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Application Berberine Chloride may be used as a pharmaceutical secondary reference standard for the determination of the analyte in biological fluids[1] by high performance liquid chromatography techniques. These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Fluorescent stain for heparin in mast cells Biochem/physiol Actions An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5´-methoxyhydnocarpin (5´-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs. Analysis Note These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. Other Notes This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. Footnote To see an example of a Certificate of Analysis for this material enter LRAB5522 in the slot below. This is an example certificate only and may not be the lot that you receive.