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Description_x000D_
General description_x000D_
The gene encoding this protein is localized on human chromosome 1q23.3._x000D_
Biochem/physiol Actions_x000D_
It forms a complex with phosphatase 2A, heat shock protein 90 (Hsp90) and cytosolic CAR retention protein in the cytoplasm. On activation, it translocates to the nucleus and modulates the expression of genes associated with drug metabolism. The protein regulates transforming growth factor-β (TGF-β) signaling._x000D_
The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury._x000D_
Physical form_x000D_
Clear and colorless frozen liquid solution_x000D_
Preparation Note_x000D_
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
- biological source human recombinant