COLCHICINE

Description_x000D_ General description_x000D_ Colchicine is a secondary metabolite, which has anti-inflammatory properties. It is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, Behçet disease, vasculitides and pericarditis. Colchicine inhibits cell division, intracellular vesicle motility, secretion of cytokines and chemokines. It is implicated in leukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space._x000D_ Application_x000D_ Colchicine has been used:_x000D_ • in the in vitro sister-chromatid exchange (SCE) assay_x000D_ • to study its in vitro antiviral, antibacterial, antifungal and cytotoxic activities_x000D_ • in microtubule disruption_x000D_ • to analyse its effects on Ca2+ transients from taxol-treated cells_x000D_ Packaging_x000D_ 1, 5 g in poly bottle_x000D_ 100, 500 mg in poly bottle_x000D_ Biochem/physiol Actions_x000D_ Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway._x000D_ Features and Benefits_x000D_ This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC