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Description
General description
Cyclosporin A (CsA) is a fungal metabolite, a cyclic undecapeptide. It has highly specific immunosuppressive effects with low myelotoxicity, thereby making it a valuable drug in human organ transplantation. Its immunosuppressive activity is based upon its ability to inhibit early steps of T-lymphocyte activation such as lymphokine gene transcription.
Cyclosporin A has been used to:
• Prevent rejection of kidney and liver transplants.
• In graft versus host disease.
• Treatment of autoimmune diseases.
• Treatment of Schistosomiasis.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Legal Information
VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH
- Related Categories Analytical Standards, Analytical/Chromatography, Immunosuppressants, Pharmaceuticals, Illicit Drugs & Alcohol Quality Level
