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Description_x000D_
General description_x000D_
During development, neuropilin-1 (NRP-1) is expressed in arteries. It is also a co-receptor of semaphorin-3a._x000D_
Specificity_x000D_
Shows no cross-reactivity with recombinant rat neuropilin-2._x000D_
Immunogen_x000D_
purified, NS0-derived, recombinant rat neuropilin-1._x000D_
Physical form_x000D_
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline._x000D_
Biochem/physiol Actions_x000D_
Neuropilin-1 (NRP-1) has been shown to play an important role in vascular and neural functions. Neuropilin 1 (Nrp1) acts as a coreceptor for VEGF receptor 2 (VEGFR2) and increases the binding of VEGF165 to VEGFR2- and VEGF165-mediated chemotaxis. In transgenic mice, Nrp1 is implicated in embryonic vascular development. Elevated expression of the gene leads to the formation of excess capillaries and haemorrhaging.
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