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Description_x000D_
General description_x000D_
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis._x000D_
Physical form_x000D_
Solution in PBS._x000D_
Other Notes_x000D_
Signal peptide and mouse progranulin (aa 1-589) are fused at the C-terminus to a FLAG®-tag._x000D_
Legal Information_x000D_
FLAG is a registered trademark of Sigma-Aldrich Co. LLC
- Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, ProgranulinMore... biological source
