ZM 336372 1PC X 1MG

Description General description A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold greater potency compared to B-Raf. Has no significant effect on many other protein kinases tested (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM). A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP. Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target Protein kinase c-Raf Product competes with ATP. Reversible: yes Target IC50: 70 nM against protein kinase c-Raf Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C. Other Notes Hall-Jackson, C.A., et al. 1999. Chem. Biol.6, 559. Legal Information Sold under license of PCT Application W098/22,103.