Description_x000D_ Application_x000D_ 3-Isobutyl-1-methylxanthine, an inhibitor of adenosine 3′,5′-cyclic monophosphate phosphodiesterase (cAMP PDE), has been used:_x000D_ • for adipogenic differentiation_x000D_ • in tissue culture_x000D_ • 3T3-L1 preadipocyte differentiation(_x000D_ Packaging_x000D_ 1 g in poly bottle_x000D_ Biochem/physiol Actions_x000D_ The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons._x000D_ Features and Benefits_x000D_ • Trace element testing by ICP_x000D_ • ICP testing for trace sulfur (as sulfate) and phosphorus (as phosphate) content_x000D_ • Ion chromatography testing for trace ammonium content