4-Hydroxynonenal

Description General description 4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. A major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca2+ and irreversibly inhibits Na+, K+-ATPase activity (IC50 = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK). A major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca2+. Irreversibly inhibits Na+-K+-ATPase activity (IC50 = 120 µM). Packaging 1 mg in Glass bottle Biochem/physiol Actions Primary Target Na+, K+-ATPase activity Product does not compete with ATP. Target IC50: 120 µM against Na+, K+-ATPase activity Warning Toxicity: Flammable (J) Physical form Supplied at 10 mg/ml in ethanol Reconstitution Following initial thaw, aliquot and freeze (-70°C). Other Notes Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. Soh, Y., et al. 2000. Mol. Pharmacol.58, 535. Carini, R., et al. 1996. Biochem. Biophys. Res. Commun.218, 772. Li, L., et al. 1996. Toxicol.Appl. Pharmacol.139, 135. Siems, W.G., et al. 1996. Free Radic. Res.20, 215. Ullrich, O., et al. 1996. Free Radic. Res.24, 421. van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420. Esterbauer, H., et al. 1991. Free Radic. Biol. Med.11, 81.