#40-SECRETASE INHIBITOR I 1PC X 1MG

Description General description A potent, cell-permeable, reversible γ-secretase inhibitor that preferentially appears to inhibit the secretion of Aβ1-40 (>90%) over Aβ1-42 (~15%). Aβtotal IC50 ~ 15 µM; Aβ1-40 IC50 ~ 22 µM; Aβ1-42 IC50 > 50 µM in CHO cells stable transfected with the cDNA encoding βAPP695. Reported to be about 10-fold more potent than Z-Val-Phe-CHO (MDL 28170; Cat. No. 208722). A potent, cell-permeable, reversible inhibitor of γ-secretase that is reported to preferentially inhibit the secretion of Aβ1-40 (>90%) vs. Aβ1-42. IC50 = ~15 µM for Aβtotal; ~22 µM for Aβ1-40; and >50 µM for Aβ1-42 in CHO cells stably transfected with the cDNA encoding βAPP695. Reported to be about 10-fold more potent than Z-Val-Phe-CHO [MDL 28170 (Cat. No. 208722)]. Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target secretion of Aβ₁₋₄₀ Product does not compete with ATP. Reversible: yes Target IC50: ~ 15 µM for Aβtotal; ~ 22 µM for Aβ1-40; < 50 µM for Aβ1-42 in CHO cells stable transfected with the cDNA encoding βAPP695 Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Sequence trans-3,5-DMC-Ile-Leu-CHO (DMC = Dimethoxycinnamoyl) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Other Notes Higaki, J.N., et al. 1999. J. Med. Chem. 42, 3889.