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Description
General description
6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.
Application
Reactant involved in:
• Synthesis of 5,6-dihydrophenanthridine sulfonamides
• Oxidative coupling with diphenylacetylene
• Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides
Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:
• Potassium channel KV1.3 and IK-1 inhibitors
• HIV-1 integrase inhibitors
Packaging
1 g in glass bottle
- Related Categories Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, N-Containing, Other Heterocyclic Building Blocks More... Quality Level
