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Description_x000D_
Amino Acid Sequence_x000D_
Ac-Tyr-Val-Ala-Asp-Chloromethylketone_x000D_
Application_x000D_
Ac-YVAD-cmk has been used:_x000D_
• as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation_x000D_
• as a caspase-1 inhibitor injected to C57BL/6 mice_x000D_
• as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury_x000D_
• to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)_x000D_
• as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth in vivo condition_x000D_
Packaging_x000D_
1, 5 mg in glass bottle_x000D_
Biochem/physiol Actions_x000D_
Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β._x000D_
Features and Benefits_x000D_
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
- Related Categories A-AM, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Caspase 1, Caspases, Caspases Inhibitors, Cell Biology, Cell Signaling and NeuroscienceMore... Quality Level