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ACETYL COENZYME A LITHIUM SALT, >=93%&
Кат. №: A2181-5MG
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Description_x000D_
Application_x000D_
Acetyl coenzyme A is suitable in CAT reporter assay for the measurement of chloramphenicol acetyltransferase by incubating the cell extract with 0.1 μCi [14C] chloramphenicol and 0.5mM acetyl-CoA._x000D_
An essential cofactor in enzymatic acetyl transfer reactions._x000D_
Packaging_x000D_
1, 5 mg in glass bottle_x000D_
10, 25, 100 mg in poly bottle_x000D_
Biochem/physiol Actions_x000D_
Alterations in the gene encoding acetyl-CoA have been linked to Alzheimer′s disease and mild cognitive impairment. Defects in the gene cause myasthenic syndrome associated with episodic apnea._x000D_
Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins._x000D_
Physical properties_x000D_
This moisture-sensitive powder should be stored desiccated at −20°C._x000D_
Preparation Note_x000D_
Prepared enzymatically_x000D_
Reconstitution_x000D_
Acetyl CoA is soluble in deionized water at 100 mg/mL. Acetyl CoA is stable in neutral and moderately acidic solutions but will hydrolyze in alkaline and strongly acidic solutions. Aqueous solutions stored in single-use aliquots are stable for up to two weeks at −20°C and up to 6 months at −80°C._x000D_
Other Notes_x000D_
For more more technical information and a complete list of Coenzyme A deriviatives visit the Acyl Transfer Reagents Resource.
- Related Categories Biochemicals and Reagents, Cell Biology, Coenzyme A and Other Acyl Transfer Reagents, Cofactors, Core Bioreagents, Enzymes, Inhibitors, and Substrates, Fatty Acid Metabolism, Fatty Acyls, Fatty Esters, Fatty acyl CoAs, Lipid, Lipids, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Mevalonate Pathway, Nucleosides and Nucleotides, Research Essentials, Terpenoid MetabolismMore... Quality Level