ACRIFLAVINE NEUTRAL

Description_x000D_ Application_x000D_ Acriflavine is used to fluorescently label high molecular weight RNA molecules ._x000D_ Excitation and emission wavelengths in various solvents :_x000D_ • Methanol: λex = 424 nm; λem = 518 nm_x000D_ • Ethanol: λex = 426 nm; λem = 524 nm_x000D_ • Propanol: λex = 430 nm; λem = 512 nm_x000D_ • Butanol: λex = 430 nm; λem = 526 nm_x000D_ • Formamide: λex = 434 nm; λem = 524 nm_x000D_ • Glycerol: λex = 432 nm; λem = 540 nm_x000D_ • Water: λex = 416 nm; λem = 514 nm_x000D_ Insoluble in ether, chloroform, and fixed oils. Utilized in fluorescence steady state measurements as a donor molecule (when paired with rhodamine 6G as the acceptor) to function as a pH sensor ._x000D_ • Acriflavine has been used in the agglutination test to distinguish between smooth and rough colony formation of Brucella melitensis._x000D_ • It has been used as an Ago2 (argonaute 2) inhibitor._x000D_ • It has been used as an inhibitor of HIF-ARNT (hypoxia-inducible factor - aryl hydrocarbon receptor nuclear translocator) complex formation._x000D_ • It has been used to study the bacteriocin production by Carnobacterium piscicola._x000D_ Packaging_x000D_ 25, 100 g in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Acriflavine also interacts with HIF-1α (hypoxia-inducible factor 1 α) and HIF-2α, and thereby suppresses dimer formation of HIF-1 and transcriptional function. It also has negative effect on tumor growth and vascularization. Acriflavine also exhibits trypanocidal, antibacterial and antiviral activities.