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Description_x000D_
Packaging_x000D_
5, 25 mg in glass bottle_x000D_
Biochem/physiol Actions_x000D_
AEG3284 is a compound that binds to HSP90, leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of JNK activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis._x000D_
Features and Benefits_x000D_
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here._x000D_
Legal Information_x000D_
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
- Related Categories A-AM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Chaperonins and Heat Shock Proteins, Heat Shock and Related Proteins, Kinase/Phosphatase Biology, Nitric Oxide and Cell Stress, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, c-Jun N-Terminal Kinase (JNK)More... Quality Level
