AMYLOID-B-PROTEIN FRAGMENT 1-40

Description_x000D_ Amino Acid Sequence_x000D_ Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val_x000D_ General description_x000D_ Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present in the vascular amyloid deposits. Aβ40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a α-helical structure in a water-micelle medium._x000D_ Application_x000D_ Amyloid β Protein Fragment 1-40 has been used:_x000D_ • in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studies_x000D_ • as a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head trauma_x000D_ • as a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts_x000D_ Biochem/physiol Actions_x000D_ Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease._x000D_ Amyloid β Protein Fragment 1-40 (Aβ40) forms cation based ion channels._x000D_ Reconstitution_x000D_ For maximal biological activity, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days._x000D_ Other Notes_x000D_ Lyophilized from 0.1% TFA in H2O