AMYLOID B-PROTEIN FRAGMENT 1-42

Description_x000D_ Amino Acid Sequence_x000D_ Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala_x000D_ General description_x000D_ Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3._x000D_ Application_x000D_ Amyloid β Protein Fragment 1-42 has been used:_x000D_ • for the preparation of Aβ 1-42 oligomer_x000D_ • for western blot analysis_x000D_ • for the interference test of immunomagnetic reduction (IMR) plasma Aβ42 assay_x000D_ • to study the effects of resveratrol on Aβ 1-42-induced impairment of spatial learning, memory and synaptic plasticity_x000D_ • to investigate the effect of Aβ in epithelial cell culture_x000D_ Biochem/physiol Actions_x000D_ Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties._x000D_ The predominant fragment of amyloid β-protein found in the brains of patients with Alzheimer′s disease and Down′s syndrome.