ANGIOSTATIN K1-3, HUMAN

Description_x000D_ General description_x000D_ Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50 =70 nM) relative to kringles 1-4 (ED50 = 135 nM). Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth._x000D_ Physical form_x000D_ From 20 mM sodium acetate, pH 5.5, 4% mannitol_x000D_ Reconstitution_x000D_ Centrifuge the vial prior to opening. Reconstitute in sterile distilled H/O or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.