Description_x000D_ General description_x000D_ In mammalian cells, four histone H1 variants (H1.2 to H1.5) are present in all somatic cells, and a fifth (H1.1) is restricted to thymus, testis, and spleen and possibly lymphocytic and neuronal cells. Histone H1.4 is di-methylated or acetylated at Lys26. Lys26 is located within the flexible N-terminal domain of H1.4, just preceding the globular domain._x000D_ Immunogen_x000D_ synthetic acetylated peptide corresponding to amino acids 22-33 (Ac-Lys26) of human histone H1.4._x000D_ Application_x000D_ Anti-acetyl-Histone H1.4 (Ac-Lys26) antibody produced in rabbit is suitable for western blot at a concentration of 0.5-1μg/mL using acid-extracted fraction of HL60 cells._x000D_ Anti-acetyl-Histone H1.4 (Ac-Lys26) antibody produced in rabbit has been used in western blotting._x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ H1.4 at lysine residue 26 represses transcription. Linker histone H1 binds to DNA between nucleosomal core particles and is involved in establishing and maintaining higher order chromatin structures. Histone modifications are thought to play an important role in cancer and disease.