ANTI-ATG12

Description_x000D_ General description_x000D_ Atg12 is an autophagy-related protein. It forms a complex with Atg5 and functions in LC3 processing._x000D_ The autophagy-related protein 3 (ATG3) gene is mapped to human chromosome 5q22.3. ATG12 is a mammalian homolog of yeast Apg3p/ Atg3 is ubiquitously expressed in human tissues._x000D_ Immunogen_x000D_ synthetic peptide corresponding to amino acids 27-39 of mouse Atg12, conjugated to KLH. The corresponding sequence differs by one amino acid in human._x000D_ Application_x000D_ Anti-Atg12 antibody produced in rabbit has been used for:_x000D_ • immunoprecipitation_x000D_ • western blot_x000D_ • immunohistochemistry staining._x000D_ Physical form_x000D_ Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Macroautophagy, usually referred to as autophagy, is a major pathway for bulk degradation of cytoplasmic constituents and organelles. Atg12 is a ubiquitin-like modifier essential for autophagy. Two ubiquitin-like conjugation systems are involved in autophagosome formation: Atg12 and Atg8 conjugation systems. Autophagy is required for normal turnover of cellular components during starvation. It plays an essential role in cellular differentiation, cell death and aging. Defective autophagy may contribute to certain human diseases such as cancer, neurodegenerative diseases, muscular disorders and pathogen infections.