Description_x000D_ General description_x000D_ Cluster of differentiation 10 (CD10) is also known as neprilysin (NEP), that is encoded by MME (membrane metallo-endopeptidase) gene. It has 24 exons and is located on chromosome 3q25.1 to q25.2. It is predominantly expressed in kidney. The protein is made of 742 amino acids with molecular weight of nearly 85 to 110kDa._x000D_ The antibody detects endogenous level of total CD10 protein._x000D_ Immunogen_x000D_ Peptide sequence around aa. 6-10 (S-Q-M-D-I), according to the protein NP_000893.2_x000D_ Target description_x000D_ Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers._x000D_ Physical form_x000D_ Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Cluster of differentiation 10 (CD10) plays an important role in the degeneration of neuropeptides. It participates in several renal diseases. It plays a major role in Alzheimer′s disease. It helps in the degradation of β‐amyloid (Aβ) in the central nervous system (CNS)._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.