ANTI-CD40 LIGAND, DEVELOPED IN GOAT, AFF

Description_x000D_ Immunogen_x000D_ purified recombinant human CD40 ligand C-terminal extracellular domain, expressed in E. coli._x000D_ Application_x000D_ Anti-CD40 Ligand antibody produced in goat is suitable for flow cytometry and western blotting at a concentration of 1μg/mL._x000D_ Physical form_x000D_ Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ CD40 Ligand is a protein that is primarily expressed on activated T cells and belongs to the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC). The expression and primary function of the cell surface receptor CD40 and its ligand CD154 were not only restricted to B and T lymphocytes, but is also associated with pathogenic processes of chronic inflammatory diseases, such as autoimmune diseases, neurodegenerative disorders, graft-versus-host disease, cancer and atherosclerosis. Over expression of CD40 Ligand (sCD40L) were found in serum but not in plasma of patients with chronic spontaneous urticaria (CU).