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ANTI-CHOLERA TOXIN-PEROXIDASE ANTIBODY P
Кат. №: SAB4200826-1VL
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Description_x000D_
General description_x000D_
Cholera toxin (CTx) also known as choleragen, is an enterotoxin produced by the Gram-negative bacterium Vibrio cholerae that naturally habitat in fresh or saltwater environments. CTx is composed of two subunits, the toxic CTxA (~27 kDa) and non-toxic CTxB (~12 kDa) assembled with the stoichiometry AB5. The V. cholerae virulence factors CtxA and CtxB are located at the CTX phage genome integrated within the bacterial chromosome._x000D_
Specificity_x000D_
Anti-Cholera Toxin-peroxidase antibody specifically recognizes Cholera Toxin and has no cross reactivity with Staphylococcal Enterotoxin A (SEA), Staphylococcal Enterotoxin B (SEB) or Pseudomonas Exotoxin A_x000D_
Immunogen_x000D_
purified toxin from Vibrio cholera_x000D_
Application_x000D_
Anti- Cholera Toxin-Peroxidase antibody produced in rabbit has been used in direct enzyme linked immunosorbent assay._x000D_
Biochem/physiol Actions_x000D_
The A1 fragment of the cholera toxin (CTx)A subunit is translocated through the membrane of the host cell, where it catalyses the ADP-ribosylation of the α-subunit of Gs (Gsa), a regulatory component of the adenylate cyclase complex. The resulting increased level of cyclic AMP promotes a wide variety of actions, including the secretion of chloride ions in the case of intestinal epithelial cells. Most of the V. cholerae species do not cause any disease in human, but few including serotypes O1 and O139 can cause cholera pandemics. Antibodies specific for cholera toxin may be used in studies of structural and functional aspects of toxin membrane interactions and for the detection of CTxB, when used, for example, as an adjuvant when injected mucosally together with the desired antigen._x000D_
Physical form_x000D_
Supplied as a lyophilized powder_x000D_
Storage and Stability_x000D_
Store the lyophilized product at 2–8 °C. For extended storage after reconstitution, keep at –20 °C in working aliquots. Avoid repeated freeze-thaw cycles. For continuous use after reconstitution, keep at 2–8 C for up to 1 month. Solutions at working dilution should be discarded if not used within 12 hours.
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