ANTI-CT-PRO ET1(C-TERMINAL) ANTIBODY&

Description_x000D_ General description_x000D_ Endothelin 1 (ET1) is an endothelium-derived peptide. It is synthesized as an inactive form of 212 amino acids and later converted to an active 21 amino acid peptide. The gene encoding it is localized on human chromosome 6p24.1._x000D_ Endothelin-1 (ET-1), also known as Preproendothelin-1 (PPET1). PPET1 undergoes several proteolytic cleavages to yield ET-1. Endothelin-1 belongs to the Endothelin family of potent vasoconstrictor peptides. It consists of three structurally-related members, distinct in their pharmacological activities and distribution ET-1, ET-2 and ET-3._x000D_ Immunogen_x000D_ a synthetic peptide corresponding to the C-terminal region of CT-Pro ET1, conjugated to KLH._x000D_ Application_x000D_ Anti-CT-Pro ET1 (C-terminal) antibody produced in rabbit may be used in various immunochemical techniques including immunoblotting using the C-terminal region of human recombinant CTPro ET1 peptide (~5 kDa), immunohistochemistry and immunofluorescence._x000D_ Physical form_x000D_ Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Endothelin 1 (ET1) is a vasoconstrictor and is involved in pulmonary vascular homeostasis. ET1 has been linked to HIV (human immunodeficiency virus)-associated pulmonary arterial hypertension and endothelial dysfunction._x000D_ Endothelin-1 (ET-1) plays an important role in various tissues. It is involved in pathogenesis of cardiovascular diseases. Indeed, circulating ET-1 levels are increased in most cardiovascular diseases. The active ET-1 peptide and C-terminal-pro-ET1 (CT-pro-ET1) peptide plasma levels are elevated in heart failure and after acute myocardial infarction (AMI), and give prognostic information on mortality. CT-proET-1 may represent a clinically useful marker of prognosis after AMI.