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Description_x000D_
General description_x000D_
Chemokine (C-X3-C motif) ligand 1 (CX3CL1) or fractalkine is a membrane protein and part of the CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. The protein acts as a ligand for the G-protein coupled receptor CX3CR1. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and in neurons. The gene encoding it is localized on human chromosome 16q21._x000D_
Immunogen_x000D_
a peptide corresponding to 18 amino acids near the amino-terminus of human CX3CL1._x000D_
Physical form_x000D_
Solution in phosphate buffered saline containing 0.02% sodium azide_x000D_
Disclaimer_x000D_
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_
Biochem/physiol Actions_x000D_
CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)–dependent manner. The protein plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it may be involved in atherogenesis._x000D_
Linkage_x000D_
The action of this antibody can be blocked using blocking peptide SBP2099.
- Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chemokines, Antibodies to Cytokines and Growth Factors, Antibodies with Corresponding Blocking Peptides, C-E, CT-CZ, Primary AntibodiesMore... conjugate