Description_x000D_ Immunogen_x000D_ synthetic peptide corresponding to the internal domain of human estrogen-related receptor γ conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene._x000D_ Physical form_x000D_ Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide._x000D_ Biochem/physiol Actions_x000D_ Estrogen-Related Receptors (ERR) are hormone receptors that bind estrogen response elements that in turn bind specific DNA sequences and regulate transcription. Three ERRs are known, alpha, beta and gamma, with highly conserved ligand and DNA binding sequences. ERRγ is selectively expressed in brain and is an important modulator of energy balance, food intake, neuropeptide levels and response to stress.