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Description_x000D_
General description_x000D_
Exosome Component 4 (EXOSC4), also known as RNA-processing protein 41 (RRP41), is a non-catalytic component of the eukaryotic RNA exosome. The eukaryotic exosome is a 400kDa complex composed of a nine subunit catalytically inert core provides structural support and facilitates substrate recognition, and two associated catalytic subunits._x000D_
The gene EXOSC4 (exosome component 4) is mapped to human chromosome 8q24.3. The encoded protein is present in the cytoplasm as well as nucleus and has a RNase pleckstrin homology (PH) domain._x000D_
Immunogen_x000D_
peptide corresponding to the N-terminal region of human EXCSC4, conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat._x000D_
Application_x000D_
Anti-EXOSC4 antibody produced in rabbit has been used in various immunochemical techniques including immunoblotting, immunoprecipitation and immunofluorescence._x000D_
Physical form_x000D_
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_
Disclaimer_x000D_
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_
Biochem/physiol Actions_x000D_
EXOSC4 (exosome component 4) is a core component of the exosome complex and is required for the stability of the complex. The exosome complex exhibits 3′-5′ exoribonuclease function. EXOSC4 lacks ribonuclease activity but is involved in mRNA turnover.
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