ANTI-JAB1

Description_x000D_ General description_x000D_ The gene JAB1 (Jun activation domain-binding protein-1) encodes a component of COP9 signalosome that functions in the phosphorylation of specific transcription factors. The gene is mapped to human chromosome 8q13.2. The encoded protein contains 334 amino acids with a molar mass of 38kDa._x000D_ Immunogen_x000D_ synthetic peptide corresponding to amino acid residues 4-20 of human JAB1 with C-terminal added cysteine conjugated to KLH. The sequence is identical in mouse and rat._x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ The gene JAB1 (Jun activation domain-binding protein-1), also referred to as COPS5 (COP9 subunit 5), is a coactivator of AP-1 (activator protein 1) transcription factor. It is also involved in the regulation of cell cycle by degradation of the cyclin-dependent kinase inhibitor p27Kip1. It increases the levels of endogenous phospho-c-Jun by activating c-Jun amino-terminal kinase (JNK) activity. These activities are inhibited by association with macrophage migration inhibitory factor (MIF), a critical cytokine in several inflammatory responses. This binding, however, does not affect induction of the transcription factor NF (nuclear factor)-κB. It exists as a monomer and functions in deneddylation of NEDD8 (neural precursor cell expressed, developmentally down-regulated 8). It facilitates the shuttling of certain molecules between the nucleus and cytoplasm. JAB1 regulates cellular proliferation and apoptosis by modulating intracellular signaling. Overexpression of this protein has been associated with tumorigenic process.