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Description_x000D_
General description_x000D_
MUS81 structure-specific endonuclease subunit is a DNA repair gene, mapped to human chromosome 11q13.1. The encoded protein belongs to the XPF/ ERCC4 (xeroderma pigmentosum, complementation group F) protein family._x000D_
Immunogen_x000D_
MUS81 (NP_079404.2, 1 a.a. ~ 551 a.a) full-length human protein._x000D_
Sequence_x000D_
MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRHRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSAPPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT_x000D_
Physical form_x000D_
Solution in phosphate buffered saline, pH 7.4_x000D_
Disclaimer_x000D_
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_
Biochem/physiol Actions_x000D_
MUS81 plays a vital role in the metabolism of replication intermediates. In mammals, MUS81 interacts with the non-catalytic subunits essential meiotic structure-specific endonuclease (EME) 1 or EME 2 to form heterodimer complexes. These complexes have the ability to cleave replication forks (RFs) in vitro. Downregulated expression of Mus81 enhances the sensitivity of colon cancer cells to chemotherapeutic drugs by inducing S phase arrest and apoptosis through CHK1 pathway activation.
- Related Categories Alphabetical Index, Antibodies, MS-MUD, Primary Antibodies conjugate