ANTI-NF1

Description_x000D_ General description_x000D_ Anti-NF1 Antibody detects endogenous levels of total NF1 protein._x000D_ NF1 (neurofibromin 1) gene is mapped to human chromosome 17q11.2. The protein encoded contains more than 2800 amino acids._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human NF1._x000D_ Immunogen Range: 1551-1600_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ NF1 (neurofibromin 1) is a tumor suppressor gene and negatively regulates RAS (proto-oncogene, GTPase). Mutation in NF1 is strongly associated with the pathogenesis of melanoma and also causes neurofibromatosis type 1. Loss of NF1 allele results in benign neurofibromas in nonmyelinating Schwann cell and is associated with desmoplastic melanoma._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.