ANTI-PHOSPHO-SMAD3 (PSER425)

Description_x000D_ General description_x000D_ SMAD3 (SMAD family member 3) is located on human chromosome 15q22. Smad 3 belongs to the mothers against Dpp (MAD) related family of proteins._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human Smad3 around the phosphorylation site of Ser425._x000D_ Immunogen Range: 376-425_x000D_ Application_x000D_ Anti-phospho-Smad3 (pSer425) antibody has been used in immunoprecipitation and immunoblotting._x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ SMAD (homologues of the Drosophila protein, mothers against decapentaplegic (Mad) and the Caenorhabditis elegans protein Sma) proteins play an important role in the intracellular signalling of transforming growth factor β (TGFβ). Reduction in the phosphorylation level of Smad3 helps autophagy to control the endothelial-mesenchymal transition. In human arterial smooth muscle cells, suppressing siRNA of SMAD3 improves the viability of cells._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.