Description_x000D_ Immunogen_x000D_ Synthetic peptide directed towards the middle region of human YY1_x000D_ Application_x000D_ Anti-YY1 (AB2) antibody produced in rabbit is suitable for western blotting at a concentration of 1 μg/ml. For immunohistochemistry of paraffin-embedded tissue sections, a concentration of 4-8 μg/ml is suitable._x000D_ Physical form_x000D_ Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Yin Yang 1 (YY1) is a transcription factor with multiple functions in cell proliferation, differentiation, apoptosis and cell cycle progression. YY1 physically interacts with YAF2 protein; this interaction is essential for the recruitment of Polycomb group of proteins to the DNA. It also interacts with GATA3 to regulate Th2 cytokine locus and cell differentiation._x000D_ Sequence_x000D_ Synthetic peptide located within the following region: KQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPR