Description_x000D_ General description_x000D_ APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells._x000D_ Physical form_x000D_ Lyophilized from PBS._x000D_ Reconstitution_x000D_ Reconstitute with 100 μL deionized water._x000D_ Other Notes_x000D_ The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG®-tag._x000D_ Legal Information_x000D_ FLAG is a registered trademark of Sigma-Aldrich Co. LLC