ATROPINE

Description_x000D_ General description_x000D_ Atropine, a belladonna alkaloid, is an anti-muscarinic drug. It is extracted from Atropa belladonna. Atropine is an anticholinergic agent, which is linked to passive mydriasis. It blocks acetylcholine receptors in brain and has hallucinogenic effects. Atropine eye drops are used to treat uveitis and early amblyopia. It is also used to treat nerve agents._x000D_ Application_x000D_ Atropine has been used to study it′s in vitro cytotoxicity, antiviral and antimicrobial activities. It has also used to antagonize acetylcholine induced K+ current._x000D_ Atropine has been used:_x000D_ • as a tastant to analyse the bitter taste perception in Drosophila larvae_x000D_ • as a muscarinic acetylcholine autoreceptors (mAChRs) antagonist to investigate the involvement of individual mAChR subtypes in the control of synapse elimination_x000D_ • to investigate the pathways of serotonin (5-HT) action in zebrafish hearts_x000D_ Packaging_x000D_ 1, 5, 25, 100 g in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Atropine is used to treat myopia and ocular axial elongation in Asian children. Small dosage of atropine is used to slow down the heart rate._x000D_ Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors._x000D_ Features and Benefits_x000D_ This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here._x000D_ This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here._x000D_ Reconstitution_x000D_ Solutions stable for several days at 4 °C.