Description_x000D_ Packaging_x000D_ 5, 25 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ BD750 is a benzothiazole derivative that inhibits proliferation of T-cells by a mechanism that involves inhibition of STAT5 phosphorylation and expression of cyclin D3 and CDK6. In the presence of BD750, human and mouse T cells stimulated with anti-CD3/CD28, alloantigen, PMA or ConA undergo G0/G1 cell cycle arrest, but express CD25 and CD69 and secrete IL-2 and IL-4. BD750 inhibits delayed-type hypersensitivity in mice._x000D_ Features and Benefits_x000D_ This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.