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Description
General description
M.W. 11,000 and 18,000 (heterodimer).
Recombinant, human caspase-8 fused at the N- and C- termini to a His•Tag sequence and expressed in E. coli as a single polypeptide. Subsequently undergoes spontaneous autoprocessing to yield the active enzyme. Suitable for the study of enzyme regulation and kinetics, target substrate cleavage, and inhibitor screening. MW: 11000 and 18000.
Packaging
3000 u in Plastic ampoule
Warning
Toxicity: Standard Handling (A)
Unit Definition
One unit is defined as the amount of enzyme that will cleave 1.0 pmol substrate Ac-IETD-pNA (Cat. No. 368057) per min at 30°C, pH 7.4.
Physical form
In 100 mM NaCl, 50 mM HEPES, 10 mM DTT, 1 mM EDTA, 10% glycerol, 0.5% CHAPS, pH 7.4.
Reconstitution
Following initial thaw, aliquot and freeze (-70°).
Other Notes
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Boldin, M.P., et al. 1996. Cell 85, 803.
Fernandes-Alnemri, T., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 7464.
Muzio, M., et al. 1996. Cell 85, 817.
- Related Categories Application Index, Biochemicals and Reagents, Enzymes, Inhibitors, and Substrates, Protein & Nucleic Acid Isolation Quality Level
