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Description_x000D_
Application_x000D_
cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line and rat pancreatic carcinoma cell line DSL6A._x000D_
Biochem/physiol Actions_x000D_
cis-4-Hydroxy-L-proline (CHP) and its derivatives may have anticancer activity. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs._x000D_
Other Notes_x000D_
Constituent of Amanita sp. peptide toxins but not of animal proteins like collagen.
- Related Categories A - H, Amino Acids, Biochemicals and Reagents, Chemical Biology, Chemical Synthesis, Modified Amino Acids, Peptide Synthesis and Peptide Chemistry, Proline Derivatives, Unnatural Amino Acids & DerivativesMore... Quality Level
