CORE HISTONES(HUMAN)

Description_x000D_ General description_x000D_ A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Further, histone H1 combines with these histones to form 30nm fibers. These fibers have six nucleosomes per turn in a solenoid arrangement. Histone H3 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription._x000D_ Physical form_x000D_ 50 mM sodium phosphate, pH 6.9, containing 10 mM sodium chloride and 1 mM β-mercaptoethanol.