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Description_x000D_
General description_x000D_
Cyclophosphamide (CYC) is a cytotoxic alkylating agent. It is activated by the cytochrome P-450 enzyme system in the liver. It has immunomodulatory functionality and inhibits humoral and cellular immunity._x000D_
Application_x000D_
Cyclophosphamide monohydrate has been used:_x000D_
• to test its antitumor effect on TC-1 tumor cells_x000D_
• as a component of multidrug solution for isolation of resistant human burkitt lymphoma cell line_x000D_
• in testing antitumor immunity in mouse tumor cell lines_x000D_
Packaging_x000D_
1, 5, 10, 25 g in glass bottle_x000D_
Biochem/physiol Actions_x000D_
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity._x000D_
Features and Benefits_x000D_
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_
Legal Information_x000D_
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
- Related Categories ALDH1A, Apoptosis Reagents, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Breast Cancer Stem Cell Markers, CI-CZ, Cancer Research, Cancer Stem Cells, Cell Biology, Cell Signaling and Neuroscience, DNA Intercalators and Crosslinkers, DNA metabolism, Other Apoptosis Related ReagentsMore... Quality Level